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 Comparison of the effects of different routes of antipsychotic administration on pharmacokinetics and pharmacodynamics 相关领域
利培酮
药代动力学
药理学
医学
药品
药效学
抗精神病药
食品药品监督管理局
奥氮平
氟哌啶醇
口服
加药
硫利达嗪
非定型抗精神病薬
分配量
麻醉
生物利用度
氯氮平
精神科
精神分裂症（面向对象编程）
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Comparison of the effects of different routes of antipsychotic administration on pharmacokinetics and pharmacodynamics. Authors: Ereshefsky L; Department of Pharmacology, University of Texas Health Science Center at San Antonio and Clinical Research Unit, San Antonio State Hospital, 78229, USA. ereshefsky@uthscsa.edu Mascarenas CA Source: The Journal of clinical psychiatry [J Clin Psychiatry] 2003; Vol. 64 Suppl 16, pp. 18-23. Publication Type: Comparative Study; Journal Article Language: English Journal Info: Publisher: Physicians Postgraduate Press Country of Publication: United States NLM ID: 7801243 Publication Model: Print Cited Medium: Print ISSN: 0160-6689 (Print) Linking ISSN: 01606689 NLM ISO Abbreviation: J Clin Psychiatry Subsets: MEDLINE Imprint Name(s): Original Publication: Memphis, Tenn., Physicians Postgraduate Press. MeSH Terms: Schizophrenic Psychology* Antipsychotic Agents/*administration & dosage Antipsychotic Agents/*pharmacokinetics Risperidone/*administration & dosage Risperidone/*pharmacokinetics Schizophrenia/*blood Schizophrenia/*drug therapy Administration, Oral ; Biological Availability ; Clinical Trials as Topic ; Delayed-Action Preparations ; Humans ; Injections, Intramuscular ; Metabolic Clearance Rate ; Receptors, Dopamine D2/drug effects ; Receptors, Dopamine D2/metabolism Abstract: Clinicians face a dilemma when choosing between short-acting atypical antipsychotics and long-acting conventional antipsychotics. Atypical antipsychotics offer better safety and efficacy, while depot formulations of conventional antipsychotics provide more reliable drug delivery, reduced differences in peak and trough plasma levels of drug, and greater dosing precision. Risperidone was recently approved by the U.S. Food and Drug Administration as the first atypical long-acting antipsychotic medication, given as biweekly gluteal injections. This long-acting formulation is synthesized using a microsphere encapsulation process, and gradual hydrolysis of the copolymer encapsulating the drug provides a steady release of medication. Consistent with other long-acting medications, plasma drug level fluctuation is reduced more with long-acting than with oral risperidone. Analyses are currently underway to further examine safety outcomes with long-acting risperidone. Substance Nomenclature: 0 (Antipsychotic Agents) 0 (Delayed-Action Preparations) 0 (Receptors, Dopamine D2) L6UH7ZF8HC (Risperidone) Entry Date(s): Date Created: 20031219 Date Completed: 20040121 Latest Revision: 20131121 Update Code: 20200527 PMID: 14680415 |
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