| 标题 |
Structural features and functional mechanism of TonB in some Gram-negative bacteria-A review
革兰氏阴性菌TonB的结构特征及其作用机制
相关领域
周质间隙
细菌外膜
细菌
生物物理学
生物化学
生物
细胞生物学
化学
大肠杆菌
遗传学
基因
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作者：Hebin Liao , Mafeng Liu , Anchun Cheng 摘要：TonB systems of gram-negative bacteria play an important role in transportation of nutriment from outside environments. TonB systems consist of plasma membrane proteins ExbB-ExbD and periplasmic protein TonB, which provide the energy to TonB-dependent receptors to transport substrates. These substrates include iron, hemin, vitamin B12, carbohydrate and some transition metal elements. The energy supporting function of TonB relies on its special structure which contains N-terminal domain for fixation, flexible periplasmic linker Pro-rich domain and C-terminal domain for contacting receptors. The precise mechanism of TonB system is not fully understood though its structural was studied a lot. To provide insights into direction for further research of TonB, we reviewed the TonB-dependent substrates uptake, structural features, functional mechanism and expression regulation of TonB. |
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