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![]() 修正计算机程序cervus如何适应基因分型错误增加亲子鉴定的成功率
相关领域
基因分型
生物
统计
基因型
计算机科学
计算生物学
遗传学
数学
基因
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摘要:Genotypes are frequently used to identify parentage. Such analysis is notoriously vulnerable to genotyping error, and there is ongoing debate regarding how to solve this problem. Many scientists have used the computer program CERVUS to estimate parentage, and have taken advantage of its option to allow for genotyping error. In this study, we show that the likelihood equations used by versions 1.0 and 2.0 of CERVUS to accommodate genotyping error miscalculate the probability of observing an erroneous genotype. Computer simulation and reanalysis of paternity in Rum red deer show that correcting this error increases success in paternity assignment, and that there is a clear benefit to accommodating ge... 关键词: CERVUSestimationgenotype errorlikelihoodparentagepaternityMAXIMUM-LIKELIHOOD-ESTIMATIONEXTRA-PAIR PATERNITYMICROSATELLITE LOCINATURAL-POPULATIONSNULL ALLELESDNARECONSTRUCTIONINDIVIDUALSRELATEDNESSINFERENCE 分类号: Q7(分子生物学) 在线出版日期: 2020-09-22 (万方平台首次上网日期,不代表论文的发表时间) |
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