| 标题 |
 Extracellular histones are major mediators ofdeath in sepsis 细胞外组蛋白是脓毒症死亡的主要介质
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| 其它 | Hyperinflammatory responses can lead to a variety of diseases, including sepsis1. We now report that extracellular histones released in response to inflammatory challenge contribute to endothelial dysfunction, organ failure and death during sepsis. They can be targeted pharmacologically by antibody to histone or by activated protein C (APC) |
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