标题 |
Bioavailability of psychotropic drugs: historical perspective and pharmacokinetic overview
相关领域
药代动力学
药理学
生物利用度
医学
药品
药物相互作用
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AI链接 uthscsa.edu |
DOI |
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Authors: Ereshefsky L Jann MW Saklad SR Davis CM Source: The Journal of clinical psychiatry [J Clin Psychiatry] 1986 Sep; Vol. 47 Suppl, pp. 6-15. Publication Type: Clinical Trial; Journal Article Language: English Journal Info: Publisher: Physicians Postgraduate Press Country of Publication: United States NLM ID: 7801243 Publication Model: Print Cited Medium: Print ISSN: 0160-6689 (Print) Linking ISSN: 01606689 NLM ISO Abbreviation: J Clin Psychiatry Subsets: MEDLINE Imprint Name(s): Original Publication: Memphis, Tenn., Physicians Postgraduate Press. MeSH Terms: Psychotropic Drugs/*metabolism Biological Availability ; Clinical Trials as Topic ; Drug Evaluation ; Fluphenazine/analogs & derivatives ; Fluphenazine/blood ; Fluphenazine/metabolism ; Fluphenazine/therapeutic use ; Humans ; Kinetics ; Mental Disorders/blood ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Psychotropic Drugs/blood ; Psychotropic Drugs/therapeutic use ; Schizophrenia/blood ; Schizophrenia/drug therapy ; Therapeutic Equivalency ; United States ; United States Dept. of Health and Human Services ; United States Food and Drug Administration Abstract: The evolution of the federal government's role in the regulation and evaluation of generic psychotropic medications is described. To place many of the methodologic bioequivalence issues for antipsychotic agents into perspective, the pharmacokinetics of these drugs are reviewed. Appropriate methodologies for studying the pharmacokinetics and pharmacodynamics of psychotropic drugs are in early developmental stages. Many of the issues relating to bioequivalence of generic products will not be resolved until a better understanding of these factors is developed. Substance Nomenclature: 0 (Psychotropic Drugs) FMU62K1L3C (fluphenazine depot) S79426A41Z (Fluphenazine) Entry Date(s): Date Created: 19860901 Date Completed: 19861020 Latest Revision: 20131121 Update Code: 20200527 PMID: 3528134 |
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