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 HGCJAMH: A Method for circRNA-Drug Sensitivity Prediction Based on Higher-Order Moment-Guided Model and Hypergraph Jumping Learning Mechanism |
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Article Number 169532 Published DEC 15 2025 Early Access NOV 2025 Indexed 2025-11-28 Document Type Article Abstract Circular RNAs (circRNAs) play a key role in regulating cellular drug sensitivity, and they hold significant promise as potential biomarkers in disease treatment and precision medicine. However, existing circRNA-drug sensitivity association (CDSA) prediction methods generally face the following challenges: high dependence on wet experiments, sparse association data leading to a high percentage of false negatives, insufficient expression of embedded features, and inadequate modeling of higher-order heterogeneous relationships. |
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(2025-6-4)
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