表观遗传学
表观遗传学
黄斑变性
疾病
医学
生物信息学
后生
机制(生物学)
神经科学
生物
遗传学
基因表达
基因
DNA甲基化
病理
眼科
作者
Valerio Caputo,Claudia Strafella,Andrea Termine,Carlo Fabrizio,Paola Ruffo,Andrea Cusumano,Emiliano Giardina,Federico Ricci,Raffaella Cascella
标识
DOI:10.1177/11206721211028054
摘要
Epigenetics is characterized by molecular modifications able to shape gene expression profiles in response to inner and external stimuli. Therefore, epigenetic elements are able to provide intriguing and useful information for the comprehension and management of different human conditions, including aging process, and diseases. On this subject, Age-related Macular Degeneration (AMD) represents one of the most frequent age-related disorders, dramatically affecting the quality of life of older adults worldwide. The etiopathogenesis is characterized by an interplay among multiple genetic and non-genetic factors, which have been extensively studied. Nevertheless, a deeper dissection of molecular machinery associated with risk, onset, progression and effectiveness of therapies is still missing. In this regard, epigenetic signals may be further explored to disentangle disease etiopathogenesis, the possible therapeutic avenues and the differential response to AMD treatment. This review will discuss the epigenomic signatures mostly investigated in AMD, which could be applied to improve the knowledge of disease mechanisms and to set-up novel or modified treatment options.
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