微泡
外体
药物输送
体内
靶向给药
癌症研究
超顺磁性
纳米技术
癌症
肿瘤微环境
医学
纳米载体
细胞生物学
小RNA
血管生成
纳米医学
材料科学
细胞外小泡
纳米颗粒
化学
生物
生物化学
内科学
磁场
磁化
生物技术
物理
基因
量子力学
作者
Hongzhao Qi,Chaoyong Liu,Lixia Long,Yu Ren,Shanshan Zhang,Xiaoping Chang,Qian Xiao-min,Huanhuan Jia,Jin Zhao,Jinjin Sun,Xin Hou,Xubo Yuan,Chunsheng Kang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2016-03-07
卷期号:10 (3): 3323-3333
被引量:336
标识
DOI:10.1021/acsnano.5b06939
摘要
Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously by mammalian cells. Clinical applications for exosomes remain a challenge because of their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed a dual-functional exosome-based superparamagnetic nanoparticle cluster as a targeted drug delivery vehicle for cancer therapy. The resulting exosome-based drug delivery vehicle exhibits superparamagnetic behavior at room temperature, with a stronger response to an external magnetic field than individual superparamagnetic nanoparticles. These properties enable exosomes to be separated from the blood and to target diseased cells. In vivo studies using murine hepatoma 22 subcutaneous cancer cells showed that drug-loaded exosome-based vehicle delivery enhanced cancer targeting under an external magnetic field and suppressed tumor growth. Our developments overcome major barriers to the utility of exosomes for cancer application.
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