Wnt信号通路
连环蛋白
细胞生物学
LRP6型
连环素
信号转导
LRP5
生物
化学
作者
Katsumi Fumoto,Akira Kikuchi
出处
期刊:PubMed
日期:2019-03-01
卷期号:29 (3): 283-289
被引量:1
摘要
The Wnt signaling pathways are classified into the β-catenin dependent pathway, which regulates gene expression through β-catenin, and the β-catenin independent pathway, which does cytoskeletal rearrangement in a β-catenin independent manner. The former is also called as the canonical Wnt signaling pathway and extensively studied in development, tumorigenesis, and regenerative research. Recently, novel mechanistic insights into the canonical Wnt signaling pathway have been clarified through the analysis of structure of Wnt-receptor complex, regulation of Wnt signaling at the cell surface membrane, and intracellular protein complex of Wnt complexes.
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