抗药性
药品
精密医学
医学
机制(生物学)
癌症
化疗
药理学
抗癌药物
生物信息学
癌症研究
生物
内科学
病理
遗传学
哲学
认识论
作者
Xinming Li,Mingdong Li,Meiying Huang,Qianyi Lin,Qiuping Fang,Jianjiang Liu,Xiaohui Chen,Li-Yun Lin,Xuliang Zhan,Huisi Shan,Deshuai Lu,Qinlan Li,Zesong Li,Xiao Zhu
标识
DOI:10.1016/j.biopha.2022.113064
摘要
Clinically, cancer drug therapy is still dominated by chemotherapy drugs. Although the emergence of targeted drugs has greatly improved the survival rate of patients with advanced cancer, drug resistance has always been a difficult problem in clinical cancer treatment. At the current level of medicine, most drugs cannot escape the fate of drug resistance. With the emergence and development of gene detection, liquid biopsy ctDNA technology, and single-cell sequencing technology, the molecular mechanism of tumor drug resistance has gradually emerged. Drugs can also be updated in response to drug resistance mechanisms and bring higher survival benefits. The use of new drugs often leads to new mechanisms of resistance. In this review, the multi-molecular mechanisms of drug resistance are introduced, and the overcoming of drug resistance is discussed from the perspective of the tumor microenvironment.
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