医学
神经纤维瘤病
结节性硬化
遗传倾向
李-弗劳门尼综合征
放射治疗
胶质瘤
癌症
肿瘤科
结直肠癌
人口
生物信息学
内科学
突变
病理
种系突变
疾病
癌症研究
遗传学
生物
环境卫生
基因
作者
Keng Lam,Carlos Kamiya-Matsuoka,John M. Slopis,Ian E. McCutcheon,Nazanin Majd
出处
期刊:JCO precision oncology
[American Society of Clinical Oncology]
日期:2024-02-01
卷期号: (8)
摘要
The purpose of this article was to provide an overview of syndromic gliomas.The authors conducted a nonsystematic literature review.Cancer predisposition syndromes (CPSs) are genetic conditions that increase one's risk for certain types of cancer compared with the general population. Syndromes that can predispose one to developing gliomas include neurofibromatosis, Li-Fraumeni syndrome, Lynch syndrome, and tuberous sclerosis complex. The standard treatment for sporadic glioma may involve resection, radiation therapy, and/or alkylating chemotherapy. However, DNA-damaging approaches, such as radiation and alkylating agents, may increase the risk of secondary malignancies and other complications in patients with CPSs. In some cases, depending on genetic aberrations, targeted therapies or immunotherapeutic approaches may be considered. Data on clinical characteristics, therapeutic strategies, and prognosis of syndromic gliomas remain limited.In this review, we provide an overview of syndromic gliomas with a focus on management for patients with CPSs and the role of novel treatments that can be considered.
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