纳米医学
细胞外基质
纳米颗粒
纳米技术
生物物理学
化学
细胞外
基质(化学分析)
材料科学
生物
生物化学
色谱法
作者
Yachao Tian,Tianfu Cheng,Fuwei Sun,Yaxin Zhou,Y. Chào,Zengwang Guo,Zhongjiang Wang
标识
DOI:10.1016/j.cis.2024.103124
摘要
Nanomedicine has a profound impact on various research domains including drug delivery, diagnostics, theranostics, and regenerative medicine. Nevertheless, the clinical translation of nanomedicines for solid cancer remains limited due to the abundant physiological and pathological barriers in tumor that hinder the intratumoral penetration and distribution of these nanomedicines. In this article, we review the dynamic remodeling of tumor extracellular matrix during the tumor progression, discuss the impact of biophysical obstacles within tumors on the penetration and distribution of nanomedicines within the solid tumor and collect innovative approaches to surmount these obstacles for improving the penetration and accumulation of nanomedicines in tumor. Furthermore, we dissect the challenges and opportunities of the respective approaches, and propose potential avenues for future investigations. The purpose of this review is to provide a perspective guideline on how to effectively enhance the penetration of nanomedicines within tumors using promising methods.
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