星形胶质细胞
感觉系统
受体
胡须
木桶(钟表)
神经科学
筒状皮质
化学
生物
生物化学
中枢神经系统
材料科学
物理化学
复合材料
作者
Noushin Ahmadpour,Meher Kantroo,Jillian L. Stobart,Jessica Meza-Resillas,Shahin Shabanipour,Jesus Parra-Nuñez,Tetiana Salamovska,Anna Muzaleva,Finnegan O’Hara,Dustin Erickson,Bruno Di Gaetano,Sofia Carrion-Falgarona,Bruno Weber,Alister Lamont,Natalie Lavine,Tiina M. Kauppinen,Michael Jackson,Jillian L. Stobart
标识
DOI:10.1038/s41467-024-45989-3
摘要
Abstract Astrocytes express ionotropic receptors, including N-methyl-D-aspartate receptors (NMDARs). However, the contribution of NMDARs to astrocyte-neuron interactions, particularly in vivo, has not been elucidated. Here we show that a knockdown approach to selectively reduce NMDARs in mouse cortical astrocytes decreases astrocyte Ca 2+ transients evoked by sensory stimulation. Astrocyte NMDAR knockdown also impairs nearby neuronal circuits by elevating spontaneous neuron activity and limiting neuronal recruitment, synchronization, and adaptation during sensory stimulation. Furthermore, this compromises the optimal processing of sensory information since the sensory acuity of the mice is reduced during a whisker-dependent tactile discrimination task. Lastly, we rescue the effects of astrocyte NMDAR knockdown on neurons and improve the tactile acuity of the animal by supplying exogenous ATP. Overall, our findings show that astrocytes can respond to nearby neuronal activity via their NMDAR, and that these receptors are an important component for purinergic signaling that regulate astrocyte-neuron interactions and cortical sensory discrimination in vivo.
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