香豆素
级联
自由基环化
化学
组合化学
激进的
计算化学
有机化学
色谱法
作者
Shuo Zhang,Wei Tang,Kai Zhou,Xiao-Xiao Huan,Zhiwei Chen
出处
期刊:Mini-reviews in Organic Chemistry
[Bentham Science]
日期:2024-01-04
卷期号:21
标识
DOI:10.2174/0118756298278048231205053801
摘要
Abstract: Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metalcatalyzed or high-temperature cyclization, which is more in line with the advocates of green chemistry. The design of alkenes or alkynes as radical acceptors for cascade reactions presents a novel and robust approach to obtaining coumarin or quinolin-2-one molecules. These radical cascade cyclization reactions have been well explored and studied over the past decade. As a result, we have compiled a review of the rapidly developing cutting-edge research in this field, featuring typical examples and in-depth exploration of the underlying mechanisms.
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