Silk Sericin: A Promising Sustainable Natural Biopolymer for Pharmaceutical and Biomedical Applications

Abstract: Silk Sericin, a natural biopolymer, has gained increasing attention for its diverse applications in pharmaceuticals and biomedicine. This is an organic biomaterial derived from the Silkworm cocoon (silkworm Bombyx mori), by the degumming process, which exhibits remarkable biocompatibility, biodegradability, making it a promising candidate for various therapeutic and regenerative approaches. Sericinhas an excellent property that makes it a potential candidate for wound healing, skin care, and drug delivery applications. This hydrophilic protein is recognized as an anti-inflammatory, antioxidant, and anti-cancer agent. The high molecular weight and granular protein composition of sericin give it a sticky consistency and gelatin-like quality. The presence of many hydroxyl groups absorbs significant water from the skin, providing a natural moisturizing effect. Silk sericin presents a sustainable alternative to synthetic polymers, boasting exceptional characteristics, including minimal immune response, excellent moisture retention, and versatility in forming various structures such as films, fibers, and hydrogels. The sustained release of sericin from wound dressings can also be efficacious in providing a prolonged healing effect during the treatment of pressure ulcers. This can contribute to a more favourable environment for faster and effective wound healing. This review aims to provide a comprehensive overview of silksericin, highlighting its unique characteristics, extraction methods, and recent advancements in its utilization for pharmaceutical and biomedical purposes, along with emphasizing the significant potential of this protein as a versatile biopolymer for advanced healthcare solutions.