Development and Validation of a Clinical, CT, Genomic Classifier and BAL Scoring System for Diagnosing IPF

医学 分类器(UML) 计算生物学 人工智能 生物 计算机科学
作者
Michelle Li Wei Kam,E. Tjong,Sachin Chaudhary,Tilman Koelsch,Joseph B. Pryor,Matthew Koslow,Michael P. Mohning,Joshua J. Solomon,Tristan J. Huie,Jeffrey J. Swigris,Evans R. Fernández Pérez
出处
期刊:The European respiratory journal [European Respiratory Society]
卷期号:: 2401077-2401077 被引量:2
标识
DOI:10.1183/13993003.01077-2024
摘要

The utility of incorporating a usual interstitial pneumonia (UIP) genomic classifier (GC) and bronchoalveolar lavage (BAL) cell count analysis alongside traditional clinical-imaging assessment in aiding in the multidisciplinary diagnosis of IPF in patients with a non-definite HRCT UIP pattern is uncertain.We reviewed consecutive adult patients presenting with fibrotic interstitial lung disease (fILD) and non-definite HRCT UIP pattern who underwent BAL and GC. The initial fILD diagnoses were re-evaluated after bronchoscopy and a final multidisciplinary consensus diagnosis was provided. We created a clinical score by analyzing fILD clinical characteristics, GC, and BAL results from 139 National Jewish Health (NJH) patients and validated it at the University of Arizona, n=52. A multivariable model was developed and assessed using receiver operating characteristic curves.43/139 (31%) and 29/52 (56%) of patients in the derivation and validation cohort, respectively, were diagnosed with IPF after bronchoscopy, and 85/139 (61%) and 32/52 (61%) had a change in treatment, respectively. Compared to non-IPF, IPF patients had a similar progression-free survival (HR, 1.50; 95%CI, 0.76, 2.95). The final model, assigned a score to eight predictors: age, sex, HRCT probable UIP pattern, exposures, connective tissue disease signs/symptoms, Velcro crackles, CG results, and BAL lymphocyte and monocyte count. The final score demonstrated an AUC of 0.90 (95% CI 0.85 to 0.95) in the derivation cohort and 0.91 (95% CI 0.83 to 0.99) in the validation cohort.The clinical-HRCT-BAL-GC IPF score may accurately estimate the post-test probability of IPF in patients with a non-definite HRCT UIP pattern.
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