糖基化
效应器
碎片结晶区
抗体
化学
细胞生物学
计算生物学
免疫学
生物
生物化学
作者
Vidya S. Shivatare,Po‐Kai Chuang,Tzu‐Hao Tseng,Yi‐Fang Zeng,Han‐Wen Huang,Gannedi Veeranjaneyulu,Han‐Chung Wu,Chi‐Huey Wong
摘要
A comprehensive structure-activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan with significant enhancement in antibody effector functions, including binding to different Fc receptors and ADCC.
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