STUDY ON THE EFFECT OF ATROPINE AT DIFFERENT CONCENTRATIONS COMBINED WITH ORTHOKERATOLOGY LENSES ON DELAYING MYOPIA IN CHILDREN AND ADOLESCENTS

Abstract Objectives To explore the clinical efficacy and safety of orthokeratology lenses combined with atropine eye drops of different concentrations in delaying the progression of low to moderate myopia in children and adolescents. Methods 150 myopic children who wore orthokeratology lenses at Henan Provincial Eye Hospital were selected and divided into three groups: 0.04% Atropine eye drops + orthokeratology lens set group (0.04ACO), 0.02% Atropine eye drops + orthokeratology lens set group (0.02ACO), 0.01% Atropine eye drops + orthokeratology lens set group (0.01ACO). After one year treatment, all patients stopped wearing orthokeratology lenses. The axial length (AL), pupil diameter, spherical equivalent (SER) and adverse drug reactions were compared. Results The SER of the subjects increased. The 0.04ACO group increased by (-0.03 ± 0.10) D. The 0.02ACO and 0.01ACO group increased by (-0.11 ± 0.10) D and (-0.29 ± 0.18) D respectively. The axial changes of the eyes in three groups of patients were 0.05 ± 0.07 mm in the 0.04ACO group, 0.09 ± 0.08 mm in the 0.02ACO group, and 0.18 ± 0.07 mm in the 0.01ACO group. After treatment, the diameters of the bright pupils (illuminance 329 ± 10LUX) were larger than those before treatment. Among the 18 patients with rapid progression, 66.67% were in a state of anxiety. Conclusion Orthokeratology lenses combined with atropine eye drops of different concentrations can synergistically delay the development of low to moderate myopia in children and adolescents. However, the combined use of 0.04% atropine eye drops has a better control effect. Acknowledgments This study was supported by project of Henan Province Medical Science and Technology Research and Development Program (No. LHGJ20220092), Leading Talents of Zhongyuan Science and Technology (No.224200510013), Natural Science Foundation of Henan Province (No.252300421269) and The Basic Research Project of Henan Eye Institute (No.20JCZD001).