Biomimetic Self-Guiding Nanomotors Boost Active Immunotherapy

, further inducing pyroptosis and increasing the immunogenicity of tumor cells, thereby activating the immune response and inhibiting the tumor growth, recurrence, and metastasis. By adopting a spatially and temporally regulated trimodality therapy strategy of chemotactic targeting, motion-induced deep penetration, and photochemoimmunotherapy, the developed nanomotors address the existing challenges in tumor therapy and allow for possible therapeutic advancements.