材料科学
生物活性玻璃
纳米颗粒
介孔材料
涂层
模拟体液
纳米技术
复合数
化学工程
铜
表面改性
介孔二氧化硅
复合材料
冶金
扫描电子显微镜
化学
有机化学
催化作用
工程类
作者
Baiyan Sui,Zhiyan Xu,Zhiyu Xue,Yong Xiang,Tian Zhou,Ana M. Beltrán,Kai Zheng,Xin Liu,Aldo R. Boccaccını
标识
DOI:10.1021/acsami.3c03680
摘要
Exploring new approaches to realize the possibility of incorporating biologically active elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) and guaranteeing their meso- structural integrity and dimensional stability has become an attractive and interesting challenge in biomaterials science. We present a postgrafting strategy for introducing different metal elements into MBG NPs. This strategy is mediated by polydopamine (PDA) coating, achieving uniform loading of copper or copper-cobalt on the particles efficiently and ensuring the stability of MBG NPs in terms of particle size, mesoporous structure, and chemical structure. However, the PDA coating reduced the ion-binding free energy of the MBG NPs for calcium and phosphate ions, resulting in the deposition of minimal CaP clusters on the PDA@MBG NP surface when immersed for 7 days in simulated body fluid, indicating the absence of hydroxyapatite mineralization.
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