化学
亲核细胞
烷基
芳基
串联
药物化学
碎片(计算)
反应条件
磷酰氯
微波辐射
序列(生物学)
组合化学
有机化学
催化作用
生物化学
材料科学
计算机科学
复合材料
操作系统
作者
Wenlai Xie,Chengzhuo Wang,Jiaxi Xu
标识
DOI:10.1021/acs.orglett.4c00881
摘要
Conversion of 1,3,5-triazinanes into 5-phosporyl-1,2,3,4-tetrahydropyrimidines is achieved efficiently through the microwave-assisted reaction with phosphoryl diazomethanes. Both trialkyl and triaryl 1,3,5-triazinanes were converted by diazomethyldiarylphosphine oxides, dialkyl diazomethylphosphonates, and alkyl diazomethyl(aryl)phosphinates and functionalized simultaneously in good to excellent yields. The reaction is a sequence of 1,3,5-triazinane fragmentation, tandem nucleophilic addition of the generated formaldimines and phosphoryl diazomethanes, and final N,N-acetalization.
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