半乳糖凝集素
上皮-间质转换
生物
细胞生物学
间充质干细胞
糖蛋白
聚糖
半乳糖凝集素-1
糖基化
半乳糖凝集素-3
糖脂
转移
背景(考古学)
癌症
癌症研究
免疫学
生物化学
遗传学
古生物学
作者
Elisa Pérez-Moreno,Claudia Oyanadel,Adely de la Peña,Ronny Hernández,Francisca Pérez-Molina,Claudia Metz,Alfonso González,Andrea Soza
标识
DOI:10.1186/s40659-024-00490-5
摘要
Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and change during processes of tissue repair, fibrosis and cancer where epithelial cells loss differentiation while acquiring migratory mesenchymal phenotypes. The epithelial-mesenchymal transition (EMT) that occurs in the context of these processes can include modifications of glycosylation patterns of glycolipids and glycoproteins affecting their interactions with galectins. Moreover, overexpression of certain galectins has been involved in the development and different outcomes of EMT. This review focuses on the roles and mechanisms of Galectin-1 (Gal-1), Gal-3, Gal-4, Gal-7 and Gal-8, which have been involved in physiologic and pathogenic EMT contexts.
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