偏肺病毒
病毒学
生物
变性肺病毒
基因敲除
病毒复制
小干扰RNA
病毒
贾纳斯激酶
信号转导
核糖核酸
呼吸道感染
呼吸系统
细胞生物学
细胞培养
基因
遗传学
解剖
作者
Y. Zhang,Guixian Wu,Yuting Yang,Linlin Niu,Yongkun Zhao
出处
期刊:Viral Immunology
[Mary Ann Liebert]
日期:2023-09-01
卷期号:36 (7): 449-457
标识
DOI:10.1089/vim.2023.0027
摘要
Respiratory virus infections are the main causes of pediatric diseases. Human metapneumovirus (hMPV) is an enveloped RNA virus similar to severe acute respiratory syndrome coronavirus type 2, both of which have emerged as important new respiratory viruses. Recent studies have found that interleukin-4 (IL-4) is involved in the replication of a variety of viruses, and its role differs in different viruses. The purpose of this study was to investigate the effect of IL-4 on hMPV and to elucidate its mechanism of action. We found that hMPV infection promoted the expression of IL-4 in human bronchial epithelial cells. The replication of the virus was reduced using small interfering RNA knockdown of IL-4 expression, while the addition of exogenous recombinant human IL-4 to IL-4 knockdown cells restored viral replication ability. These results demonstrate that the expression of IL-4 is closely related to the replication of hMPV; moreover, further experiments revealed that IL-4 promotes the replication of hMPV through a mechanism dependent on the Janus kinase/signal transductor and transcription activator 6 signaling pathway. Therefore, anti-IL-4 strategies may be a promising avenue for the treatment of hMPV infection, representing an important breakthrough for children at risk from hMPV infection.
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