Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review

CatecholamineCatecholamines stimulation over adrenergicAdrenergic receptors results in a state of hypercoagulability. Chronic stress involves the release and increase in circulation of catecholaminesCatecholamines and other stress related hormones. Numerous observational studies in human have related stressful scenarios to several coagulationCoagulation variables, but controlled stimulation with agonists or antagonists to adrenergicAdrenergic receptors are scarce. This systematic review is aimed at presenting an updated appraisal of the effect of adrenergic receptor modulation on variables related to human hemostasisHemostasis by systematically reviewing the effect of adrenergic receptor-targeting drugs on scale variables related to hemostasisHemostasis. By searching 3 databases for articles published between January 1st 2011 and February 16th, 2022 reporting effects on coagulationCoagulation parameters from stimulation with α- or β-adrenergic receptor targeting drugs in humans regardless of baseline condition, excluding records different from original research and those not addressing the main aim of this systematic review. Risk of bias assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2). Tables describing a pro-thrombotic anti-fibrinolytic state induced after β-adrenergicAdrenergic receptor agonist stimulation and the opposite after α1-, β-adrenergicAdrenergic receptor antagonist stimulation were synthesized from 4 eligible records by comparing hemostasisHemostasis-related variables to their baseline. Notwithstanding this low number of records, experimental interventions included were sound and mostly unbiased, results were coherent, and outcomes were biologically plausible. In summary, this systematic review provides a critical systematic assessment and an updated elaboration, and its shortcomings highlight the need for further investigation in the field of hematology.