Tetrahedral Framework Nucleic Acid Composite Hydrogel Loaded with Naringin for Full Alveolar Bone Regeneration

assays. Furthermore, a rat model of full-thickness alveolar bone defects was developed and treated with a chitosan hydrogel and TNC as composite scaffolds for alveolar bone regeneration. The results of morphological, immunohistochemical, and immunofluorescence analyses performed at 2 and 4 weeks posttreatment indicated that TNC effectively promoted the remodeling of the cortical and cancellous alveolar bones and shed light on the underlying molecular mechanism. Thus, TNC was concluded to combine the advantages of tFNAs and Nar and facilitate full-thickness alveolar bone repair, holding promise as a nucleic acid-based nanomaterial for bone tissue regenerative medicine.