Promoting ROS scavenging and osteogenic differentiation by metal–phenolic network nanoparticle-embedded microenvironment-responsive hydrogel for the repair of senile osteoporotic bone defects

evaluations using a geriatric osteoporotic bone defect model demonstrated significant improvements in bone mass augmentation and accelerated regeneration rates. This study shows the potential for using MPN nanoplatforms to simultaneously address bone formation deficits and elevated oxidative stress, thereby offering a promising solution for age-related osteoporotic repair.