化学
酰胺
硼烷
胺气处理
有机化学
氨
还原(数学)
小学(天文学)
甲酰胺
组合化学
还原剂
氨硼烷
硼烷
催化作用
化学还原
转化(遗传学)
热稳定性
反应条件
氧化还原
作者
Ke Xu,Min‐Jie Zhou,Xinrui Liu,Guofei Chen,Yinjun Xie
出处
期刊:Synlett
[Thieme Medical Publishers (Germany)]
日期:2025-09-19
卷期号:36 (20): 3387-3390
被引量:1
摘要
Abstract The reduction of carbonyl compounds is one of the most fundamental and useful transformations in synthetic chemistry. However, due to the high resonance stability of the amide group, reducing amide compounds is difficult and always requires harsh reductants and/or additional catalysts/additives. In this report, we describe a catalyst-free, additive-free protocol for the deoxygenative reduction of amides using ammonia borane as a mild reductant. Tertiary, secondary, and primary amides, as well as challenging imides can be reduced to the corresponding amines under these conditions. Additionally, the transformation performed well in open air, making the method more practical.
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