The Role of the TRIM Family in Lung Cancer Development: An Emerging Player with Therapeutic Potential

Abstract: Lung cancer is one of the most prevalent malignancies and a leading cause of cancer-related deaths worldwide. E3 ubiquitin ligase activity is a common feature of most TRIM proteins, highlighting the family's critical role in regulating the biological behaviors of tumor cells and influencing various cellular physiological activities, including apoptosis, innate immunity, development, and intracellular signaling. In lung cancer, certain TRIM proteins function either as oncoproteins or cancer suppressors. This review explores the unique function of TRIM in lung cancer development, focusing on the molecular processes of TRIM proteins. Finally, we provide an overview of recent advancements in the prognosis and therapeutic strategies for lung cancer involving TRIM proteins.