内化
聚乙二醇化
化学
聚乙二醇
生物物理学
PEG比率
胶束
药物输送
光动力疗法
生物化学
细胞
有机化学
生物
财务
经济
水溶液
作者
Xiaolong Zeng,Yufei Wang,Yun‐Shuai Huang,Jianxiong Han,Wen Sun,Hans‐Jürgen Butt,Xing‐Jie Liang,Si Wu
出处
期刊:Small
[Wiley]
日期:2022-11-11
卷期号:18 (52)
被引量:15
标识
DOI:10.1002/smll.202205461
摘要
Metallodrugs are widely used in cancer treatment. The modification of metallodrugs with polyethylene glycol (PEGylation) prolongs blood circulation and improves drug accumulation in tumors; it represents a general strategy for drug delivery. However, PEGylation hinders cellular internalization and tumor penetration, which reduce therapeutic efficacy. Herein, the red-light-enhanced cellular internalization and tumor penetration of a PEGylated anticancer agent, PEGylated Ru complex (Ru-PEG), are reported upon. Ru-PEG contains a red-light-cleavable PEG ligand, anticancer Ru complex moiety, and fluorescent pyrene group for imaging and self-assembly. Ru-PEG self-assembles into vesicles that circulate in the bloodstream and accumulate in the tumors. Red-light irradiation induces dePEGylation and changes the Ru-PEG vesicles to large compound micelles with smaller diameters and higher zeta potentials, which enhance tumor penetration and cellular internalization. Red-light irradiation also generates intracellular 1 O2 , which induces the death of cancer cells. This work presents a new strategy to enhance the cellular internalization and tumor penetration of anticancer agents for efficient phototherapy.
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