Many drugs have been known to cause diarrhea, although their mechanism of action has not been well described. Determining the etiology of drug-induced diarrhea depends on careful history taking to identify the offending agent. Drug-induced diarrhea may be classified as watery, inflammatory, fatty diarrhea. Treatment may vary depending on this classification and usually includes withdrawal of the offending drug. However, in some cases, diarrhea may resolve with continued use or through nonspecific agents, such as loperamide.