脂质体
结合
肽
化学
硼
共轭体系
药物输送
组合化学
固体脂质纳米粒
纳米颗粒
氨基酸
生物化学
有机化学
材料科学
纳米技术
数学分析
聚合物
数学
作者
Makoto Shirakawa,Tetsuya Yamamto,Kei Nakai,Kenichi Aburai,Sho Kawatobi,Takao Tsurubuchi,Yohei Yamamoto,Yuusaku Yokoyama,Hiroaki Okuno,Akira Matsumura
标识
DOI:10.1016/j.apradiso.2009.03.101
摘要
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron component liposome. It consisted of three different kinds of amino acid derivatives and two fatty acids, and could react directly with the peptide synthesized first on resin by Fmoc solid-phase synthesis. In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) and boronophenylalanine (BPA) was synthesized and successfully incorporated into liposomes.
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