雌激素
抗雌激素
内生
癌症
乳腺癌
医学
雌激素受体
内科学
内分泌学
生物
生物信息学
作者
Jing Liang,Yongfeng Shang
出处
期刊:Annual Review of Physiology
[Annual Reviews]
日期:2013-02-10
卷期号:75 (1): 225-240
被引量:237
标识
DOI:10.1146/annurev-physiol-030212-183708
摘要
Estrogen exhibits a broad spectrum of physiological functions ranging from regulation of the menstrual cycle and reproduction to modulation of bone density, brain function, and cholesterol mobilization. Despite the beneficial actions of endogenous estrogen, sustained exposure to exogenous estrogen is a well-established risk factor for various cancers. We summarize our current understanding of the molecular mechanisms of estrogen signaling in normal and cancer cells and discuss the major challenges to existing antiestrogen therapies.
科研通智能强力驱动
Strongly Powered by AbleSci AI