淋巴管新生
淋巴系统
淋巴管内皮
淋巴管
归巢(生物学)
CD44细胞
淋巴细胞归巢受体
病理
生物
受体
免疫学
医学
癌症研究
淋巴结
癌症
细胞
内科学
转移
细胞粘附
生态学
遗传学
作者
David G. Jackson,Remko Prevo,Steven Clasper,Suneale Banerji
标识
DOI:10.1016/s1471-4906(01)01936-6
摘要
Previous research into hyaluronan (HA) has focused on the role of this abundant tissue glycosaminoglycan in promoting cell migration through interactions with its transmembrane receptor CD44 on inflammatory leukocytes and tumor cells. The recent discovery of a new HA receptor, LYVE-1 (lymphatic vessel endothelial HA receptor), expressed predominantly in lymphatic vessels, highlights another aspect of HA biology: its continuous transit through the lymphatic system and its potential involvement in lymph node homing by CD44+ leukocytes and tumor cells. The functional role of LYVE-1 in lymphatic vessels and its application as a marker to study tumor lymphangiogenesis are important areas of investigation.
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