生物
小鼠白血病病毒
水貂
同源的
白血病
病毒
病毒学
免疫学
遗传学
基因
生态学
作者
Herbert C. Morse,Robert A. Yetter,Jack H. Stimpfling,Olin M. Pitts,T. N. Fredrickson,Janet W. Hartley
出处
期刊:Cell
[Elsevier]
日期:1985-06-01
卷期号:41 (2): 439-448
被引量:37
标识
DOI:10.1016/s0092-8674(85)80017-9
摘要
Some strains of C57BL/10 H-2-congenic mice were found to exhibit greying with age, whereas others did not. Two patterns of greying were observed, diffuse greying beginning at 4 to 6 months of age and patterned greying beginning at 4 to 6 weeks. Strains exhibiting either greying pattern expressed high levels of infectious ecotropic and mink cell focus-inducing murine leukemia viruses (MuLV) in tests of thymus and spleen and in cultures from skin or tail biopsies, whereas nongreying strains expressed little virus until late in life. Electron microscopy demonstrated large accumulations of MuLV in grey, but not in black areas, of skin from a mouse with patterned greying. Infectious MuLV was produced spontaneously by embryos of greying, but not of nongreying, mice and pups of nongreying strains fostered on greying mothers turned grey after 3 months. These results suggest that greying with age results from melanocyte dysfunction that occurs subsequent to pre- or early postnatal infection with MuLV.
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