The biosynthesis of bisorbicillinoids: evidence for a biosynthetic route from bisorbicillinol to bisorbibutenolide and bisorbicillinolide

Biosynthetic incorporation of labelled sodium acetates into bisorbicillinol in Trichoderma sp. USF-2690 suggests that bisorbicillinol is derived from 12 acetate units. Successful bioconversion of the labelled bisorbicillinols to bisorbibutenolides (bislongiquinolides) and bisorbicillinolides using the washed mycelium of the strain suggests that there are biosynthetic routes from bisorbicillinol to bisorbibutenolide and from bisorbicillinol to bisorbicillinolide.