胶质纤维酸性蛋白
老年斑
阿尔茨海默病
自身抗体
医学
退行性疾病
老年痴呆
疾病
病理
痴呆
血管性痴呆
抗体
免疫学
内科学
免疫组织化学
作者
Patrizia Mecocci,Lucilla Parnetti,Rosario Donato,Carla Santucci,A Santucci,D. Cadini,Emilio Foa,Roberta Cecchetti,Umberto Senin
标识
DOI:10.1016/0889-1591(92)90049-t
摘要
Autoantibodies against glial fibrillary acidic protein (GFAP) were investigated by ELISA test in sera of patients suffering from senile dementias and in healthy aging people. One hundred eight subjects divided into control, vascular dementia (VD), presenile Alzheimer's disease (AD), and senile Alzheimer's disease (SDAT) groups were included in the study. VD patients showed the highest antibody titers when compared to controls, whereas AD had the lowest titers when compared to the other groups. These results do not support the utility of anti-GFAP antibodies as useful markers of Alzheimer's disease, suggesting that their presence is a secondary phenomenon to blood-brain barrier disruption.
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