Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

Production of the proinflammatory cytokine IL-1β is crucial in host defense. Geijtenbeek and colleagues show that dectin-1 signaling in response to fungi and mycobacteria induces IL-1β maturation via a noncanonical caspase-8-dependent inflammasome.