神经发生
细胞外基质
材料科学
再生(生物学)
自愈水凝胶
脊髓损伤
纳米技术
体内
生物医学工程
神经科学
计算机科学
脊髓
生物
细胞生物学
工程类
高分子化学
生物技术
作者
Yusheng Zhang,Suping Chen,Zhu Xiao,Xiaoyin Liu,Chengheng Wu,Kai Wu,Amin Liu,Dan Wei,Jing Sun,Liangxue Zhou,Hongsong Fan
标识
DOI:10.1002/adhm.202100695
摘要
Abstract Electrical stimulation is regarded pivotal to promote repair of nerve injuries, however, failed to get extensive application in vivo due to the challenges in noninvasive electrical loading accompanying with construction of biomimetic cell niche. Herein, a new concept of magneto responsive electric 3D matrix for remote and wireless electrical stimulation is demonstrated. By the preparation of magnetoelectric core/shell structured Fe 3 O 4 @BaTiO 3 NPs‐loaded hyaluronan/collagen hydrogels, which recapitulate considerable magneto‐electricity and vital features of native neural extracellular matrix, the enhancement of neurogenesis both in cellular level and spinal cord injury in vivo with external pulsed magnetic field applied is proved. The findings pave the way for a novel class of remote controlling and delivering electricity through extracellular niches‐mimicked hydrogel network, arising prospects not only in neurogenesis but also in human–computer interaction with higher resolution.
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