萜类
化学
脂多糖
消炎药
化学成分
立体化学
传统医学
药理学
色谱法
生物
免疫学
医学
作者
Xiaohua Yang,Daiwei Wang,Yong‐Ming Yan,Ya‐Bin Jiao,Yong‐Xian Cheng,Feng Wang
标识
DOI:10.1002/cbdv.202100265
摘要
Abstract Commiphorane K ( 1 ), a new dinorditerpenoid, commiphoranes L−N ( 2 – 4 ), three new germacrane‐type sesquiterpenoids, and commiphorane O ( 5 ), one new guaiane‐type sesquiterpenoid, were isolated from Resina Commiphora . Their structures were characterized by spectroscopic and computational methods. In particular, the structure of 4 was confirmed by X‐ray crystallography. Compounds 2 – 5 were evaluated for their anti‐inflammatory activities. The result shows that compound 2 suppresses lipopolysaccharide (LPS)‐stimulated production of TNF‐ α in RAW264.7 cells in a dose‐dependent manner.
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