托法替尼
医学
斑秃
环状肉芽肿
STAT蛋白
脂样坏死
白癜风
贾纳斯激酶
皮肤病科
免疫学
鲁索利替尼
信号转导
类风湿性关节炎
车站3
细胞因子
骨髓
骨髓纤维化
糖尿病
化学
内分泌学
生物化学
作者
Stephanie Chapman,Linda Stein Gold,Henry W. Lim
标识
DOI:10.1016/j.jaad.2021.06.873
摘要
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is implicated in the pathogenesis of a number of inflammatory dermatoses. Clinical trials and other studies have demonstrated the efficacy of JAK inhibitors in the treatment of a variety of dermatologic conditions. Here we review JAK inhibitors currently under investigation for the treatment of alopecia areata, vitiligo, sarcoidosis, necrobiosis lipoidica, granuloma annulare, and systemic lupus erythematosus with a special emphasis on safety and the implications of JAK inhibitors during the novel coronavirus 2019 pandemic.
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