表位
共价键
非共价相互作用
蛋白质-蛋白质相互作用
化学
肽
血浆蛋白结合
计算生物学
生物物理学
细胞生物学
生物化学
生物
分子
遗传学
抗原
氢键
有机化学
作者
Brahma Ghosh,Rachel Ramoni
标识
DOI:10.1021/acschembio.1c00389
摘要
β-Strands are a fundamental component of protein structure, and these extended peptide regions serve as binding epitopes for numerous protein–protein complexes. However, synthetic mimics that capture the conformation of these epitopes and inhibit selected protein–protein interactions are rare. Here we describe covalent and noncovalent β-hairpin mimics of an extended strand region mediating the Tcf4/β-catenin interaction. Our efforts afford a rationally designed lead for an underexplored region of β-catenin, which has been the subject of numerous ligand discovery campaigns.
科研通智能强力驱动
Strongly Powered by AbleSci AI