细胞周期蛋白依赖激酶
DNA修复
DNA损伤
细胞生物学
同源重组
生物
非同源性末端接合
基因组不稳定性
细胞周期
DNA
遗传学
细胞
作者
Mateusz Kciuk,Adrianna Gielecińska,Somdutt Mujwar,Mariusz Mojzych,Renata Kontek
标识
DOI:10.1016/j.bbcan.2022.188716
摘要
The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs in DNA damage response (DDR) has emerged. CDKs affect both damage signaling and DNA repair, contributing to the fidelity of the cell division process as well as the maintenance of genomic integrity following DNA damage. This is due to the modulatory role of CDKs on double-strand break repair (DSBR) components, including their influence on enzymes involved in homologous recombination (HR) and non-homologous end-joining (NHEJ). In this review, the impact of CDKs on DDR and DNA repair is discussed.
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