化学
磷脂
磷脂酰乙醇胺
单层
磷脂酰胆碱
生物膜
膜
不饱和度
脂质双层
生物物理学
布鲁斯特角
膜流动性
分子
表面压力
脂质双层相行为
结晶学
有机化学
生物化学
物理
布鲁斯特
机械
光学
生物
作者
Daria Maltseva,Grazia Gonella,Jean‐Marie Ruysschaert,Mischa Bonn
摘要
Biomembrane hydration is crucial for understanding processes at biological interfaces. While the effect of the lipid headgroup has been studied extensively, the effect (if any) of the acyl chain chemical structure on lipid-bound interfacial water has remained elusive. We study model membranes composed of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) lipids, the most abundant lipids in biomembranes. We explore the extent to which the lipid headgroup packing and associated water organization are affected by the lipid acyl tail unsaturation and chain length. To this end, we employ a combination of surface-sensitive techniques, including sum-frequency generation spectroscopy, surface pressure measurements, and Brewster angle microscopy imaging. Our results reveal that the acyl tail structure critically affects the headgroup phosphate orientational distribution and lipid-associated water molecules, for both PE and PC lipid monolayers at the air/water interface. These insights reveal the importance of acyl chain chemistry in determining not only membrane fluidity but also membrane hydration.
科研通智能强力驱动
Strongly Powered by AbleSci AI