多囊卵巢
来曲唑
卵巢
丁酸盐
肠道菌群
激素
二甲双胍
内科学
内分泌学
医学
生物
芳香化酶
胰岛素抵抗
胰岛素
免疫学
生物化学
发酵
乳腺癌
癌症
作者
Yufeng He,Liya Mei,Luyao Wang,Xiu Li,Jianxin Zhao,Hao Zhang,Wei Chen,Gang Wang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:13 (3): 1380-1392
被引量:10
摘要
Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects women of reproductive age. The gut microbiota has been shown to play a vital role in the pathogenesis of PCOS. Agents that target microbes in the gut may be promising therapeutic strategies for PCOS. Herein, a letrozole-induced PCOS model was used to test five Lactiplantibacillus plantarum strains for their ability to alleviate PCOS symptoms and their effect on the gut-brain axis. Lp. plantarum CCFM1019 attenuated the pathological changes in the ovaries and restored testosterone and luteinising hormone levels. However, metabolic disorders induced by letrozole treatment were not significantly reversed by these strains. Meanwhile, alteration of gut microbial diversity and enrichment of the short-chain fatty acid producers Lachnospira and Ruminococcus_2 were observed after Lp. plantarum CCFM1019 intervention. Compared with letrozole-treated rats, those treated with Lp. plantarum CCFM1019 exhibited higher butyrate and polypeptide YY levels, possibly due to the regulation of G protein-coupled receptor 41 expression. These results demonstrated that Lp. plantarum CCFM1019 attenuated letrozole-induced PCOS symptoms in rats. A butyrate-dependent gut-brain mechanism may be involved in this protective effect.
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