A Walk-and-Eat Intervention Improves Outcomes for Patients With Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapy

食管癌 医学 新辅助治疗 放化疗 干预(咨询) 肿瘤科 内科学 癌症 乳腺癌 护理部
作者
Yu-Juan Xu,Jason Chia‐Hsien Cheng,Jang‐Ming Lee,Pei‐Ming Huang,Guan‐Hua Huang,Chia‐Hui Chen
出处
期刊:Oncologist [AlphaMed Press]
卷期号:20 (10): 1216-1222 被引量:80
标识
DOI:10.1634/theoncologist.2015-0178
摘要

Preserving functional walking capacity and nutritional status is important for patients with esophageal cancer, but no effective intervention is available, particularly during active treatment.This pilot randomized controlled trial tested the effects of a walk-and-eat intervention for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy. Participants with locally advanced esophageal cancer stage IIB or higher (n = 59) were randomly assigned to receive the walk-and-eat intervention (n = 30; nurse-supervised walking three times per week and weekly nutritional advice) or usual care (n = 29; control group) during 4-5 weeks of chemoradiotherapy. Primary endpoints were changes in distance on the 6-minute walk test, hand-grip strength, lean muscle mass, and body weight between initiation and completion of intervention.Participants (mean age: 59.6 years) were mostly male (92.9%) with squamous cell carcinoma (96.4%). During chemoradiotherapy, participants who received the walk-and-eat intervention had 100-m less decline than controls in walk distance (adjusted p = .012), 3-kg less decrease in hand-grip strength (adjusted p = .002), and 2.7-kg less reduction in body weight (adjusted p < .001), regardless of age. The intervention group also had significantly lower rates of need for intravenous nutritional support and wheelchair use.The nurse-led walk-and-eat intervention is feasible and effective to preserve functional walking capacity and nutritional status for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
Wang完成签到,获得积分10
2秒前
2秒前
Lina完成签到,获得积分10
2秒前
zzzhu完成签到,获得积分10
2秒前
3秒前
酷波er应助WeiYang采纳,获得10
4秒前
科研通AI5应助geold采纳,获得10
4秒前
贝儿完成签到,获得积分10
4秒前
glj关闭了glj文献求助
5秒前
Lina发布了新的文献求助10
5秒前
Owen应助科研通管家采纳,获得10
6秒前
kingwill应助科研通管家采纳,获得20
6秒前
iNk应助科研通管家采纳,获得20
6秒前
iNk应助科研通管家采纳,获得20
7秒前
所所应助收声采纳,获得10
7秒前
桐桐应助科研通管家采纳,获得10
7秒前
甜甜玫瑰应助Augenstern采纳,获得10
7秒前
upupup应助科研通管家采纳,获得10
7秒前
科研通AI2S应助科研通管家采纳,获得10
7秒前
共享精神应助科研通管家采纳,获得10
7秒前
7秒前
flame应助科研通管家采纳,获得10
7秒前
Hello应助科研通管家采纳,获得10
7秒前
小蘑菇应助科研通管家采纳,获得10
7秒前
小马甲应助科研通管家采纳,获得10
8秒前
丘比特应助科研通管家采纳,获得10
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
8秒前
科研通AI5应助断章采纳,获得10
8秒前
洪七公完成签到,获得积分10
8秒前
9秒前
9秒前
星辰大海应助qwer1234采纳,获得10
12秒前
学白柒发布了新的文献求助20
12秒前
12秒前
大菊发布了新的文献求助10
12秒前
张医生完成签到,获得积分10
12秒前
13秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Technologies supporting mass customization of apparel: A pilot project 450
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 430
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
China Gadabouts: New Frontiers of Humanitarian Nursing, 1941–51 400
The Healthy Socialist Life in Maoist China, 1949–1980 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3793698
求助须知:如何正确求助?哪些是违规求助? 3338599
关于积分的说明 10290546
捐赠科研通 3055010
什么是DOI,文献DOI怎么找? 1676285
邀请新用户注册赠送积分活动 804326
科研通“疑难数据库(出版商)”最低求助积分说明 761836