食管癌
医学
新辅助治疗
放化疗
干预(咨询)
肿瘤科
内科学
癌症
乳腺癌
护理部
作者
Yu-Juan Xu,Jason Chia‐Hsien Cheng,Jang‐Ming Lee,Pei‐Ming Huang,Guan‐Hua Huang,Chia‐Hui Chen
出处
期刊:Oncologist
[AlphaMed Press]
日期:2015-09-04
卷期号:20 (10): 1216-1222
被引量:80
标识
DOI:10.1634/theoncologist.2015-0178
摘要
Preserving functional walking capacity and nutritional status is important for patients with esophageal cancer, but no effective intervention is available, particularly during active treatment.This pilot randomized controlled trial tested the effects of a walk-and-eat intervention for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy. Participants with locally advanced esophageal cancer stage IIB or higher (n = 59) were randomly assigned to receive the walk-and-eat intervention (n = 30; nurse-supervised walking three times per week and weekly nutritional advice) or usual care (n = 29; control group) during 4-5 weeks of chemoradiotherapy. Primary endpoints were changes in distance on the 6-minute walk test, hand-grip strength, lean muscle mass, and body weight between initiation and completion of intervention.Participants (mean age: 59.6 years) were mostly male (92.9%) with squamous cell carcinoma (96.4%). During chemoradiotherapy, participants who received the walk-and-eat intervention had 100-m less decline than controls in walk distance (adjusted p = .012), 3-kg less decrease in hand-grip strength (adjusted p = .002), and 2.7-kg less reduction in body weight (adjusted p < .001), regardless of age. The intervention group also had significantly lower rates of need for intravenous nutritional support and wheelchair use.The nurse-led walk-and-eat intervention is feasible and effective to preserve functional walking capacity and nutritional status for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI