无水的
氟化物
化学
水溶液
蒸发
无机化学
放射化学
有机化学
物理
热力学
作者
Christian Lemaire,Joël Aerts,Samuël Voccia,Lionel Libert,Frédéric Mercier,David Goblet,Alain Plenevaux,André Luxen
标识
DOI:10.1002/anie.200906341
摘要
Doing without water: The 18F labeling of radiopharmaceuticals requires nearly anhydrous solutions of [18F]fluoride. Aqueous K2CO3 is generally used to elute [18F]fluoride from an anion-exchange resin. Replacing aqueous K2CO3 with strong organic bases, such as the phosphazene base P2Et (conjugate acid shown), enabled the recovery of highly reactive [18F]fluoride and avoided the azeotropic evaporation of water, which is very difficult on a microchip device. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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