The therapeutical effect of two mechanical ventilations on pulmonary edema after seawater drowning in rabbits

Objective To observe the therapeutical effect of conventional mechanical ventilation (CMV) and high frequency jet ventilation (HFJV) on pulmonary edema after seawater drowning in rabbits. Methods Twenty-eight pulmonary edema New Zealand rabbit models were randomly assigned to received CMV and HFJV treatment. Blood gas analysis, pneumodynamic, hemodynamics status and tumor necrosis factor (TNF-α) extracted from serum were monitored at various time points. After 3 hours'ventilation, 7 rabbits of each group were killed to gain lung tissues for pathology examination and lung lavage fluid was analyzed for leukocyte count. Results PaO2 and SO2 were significantly increased after the use of ventilation in pulmonary edema rabbit models(P 0.01) .especially in CMV treatment group. Pneumodynamic and hemodynamic status were ameliorated. The results of TNF-αmonitor and leukocyte count showed that lung injury were relieved. CMV treatment had better efficiency in ameliorating hypoxemia, compared with HFJV treatment. Conclusions Our study showed CMV and HFJV could significantly improve hypoxemia in PE-SWD rabbits, and to some extent, relieve lung injury.