化学
羟醛反应
立体选择性
异丙基
加合物
选择性
锂(药物)
立体化学
药物化学
有机化学
催化作用
医学
内分泌学
作者
Gopal L. Khatik,Varun Kumar,Vipin A. Nair
出处
期刊:Organic Letters
[American Chemical Society]
日期:2012-05-09
卷期号:14 (10): 2442-2445
被引量:49
摘要
Synergistic effects of the exo- and endocyclic chiral centers of an imidazolidinone-based auxiliary were investigated in the perspective of acetate aldol reactions. The reversal in diastereoselectivity was accomplished by lithium and titanium enolate reactions, which proceed through proposed open and closed transitions states, respectively. The aldol adducts were used in the stereoselective synthesis of fluoxetine.
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