医学
先天免疫系统
免疫学
人类白细胞抗原
HLA-B27
免疫
获得性免疫系统
发病机制
抗原
免疫系统
标识
DOI:10.1080/09273948.2016.1175641
摘要
HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI