It is the key that choose the reasonable water flooding mode for achieving the goal of controling water cut and keeping the stable oil production in water flooding reservoir.This areticle shows the reasonable water flooding mode of low permeability sandstone reservoir which will improve waterflood efficiency,supply reservoir pressure,slow decline of oil and develop the oilfield effectively,by taking measures such as reservoir engineering,numerical reservoir simulation and dynamic analysis,researching on water injection timing,water flooding mode,water injection intensity,separated-zone water flooding and so on in Luo 1 area which is a low permeability sandstone reservoir.